please can some one help me with this question??
Answer:
Both answers right. You've got four main areas to take into account in pharmacokinetics: Absorption, Distribution, Metabolism and Excretion in that order. If you want to look at areas of distribution then you have to create an environment where Absorption factors are independant and won't have an effect. You can bypass worrying about how much drug will reach the systemic circulation and how much will be removed by popping the drug straight in, as quickly as possible.
because you don't have to factor bioavailabilty. if you take something by mouth only a certain amount is absorbed which varies from drug to drug. if you give it straight in the blood you know 100% is bioavailable
Alex is right, you dont have to factor bioavailibilty, because all of the drug is present in the body after an intravenous bolus dose. In fact orally administered drugs are never used to calculate the volume of distribution.
Finally, its a bolus dose and not a slow intravenous dose because you are looking for peak concentration.
Rememer VD= dose/Co (Co is conc at zero time). Now if you want to maintain a particular steady state conc in the blood say Css, then you will use this formula to calculate the loading dose which will be= Vd*Css. Hope this helps you .
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